Endocrine Abstracts

Background: Antidiuretic analogue desmopressin was tested in its intranasal form in renal colic, with variable effects.Aims: We evaluated the effects of sublingual desmopressin in lithiasic renal colic, alone or combined with a non-steroidal antiinflammatory drug (NSAID).Materials and methods: Our prospective single-blind study included an initial number of 371 patients with lithiasic renal colic randomized as follows: group NSAID ...

Hyperthyroidism has significant impact upon both bone turnover and body composition. The present study was designed to investigate whether there is a connection between changes in body composition and bone mineral content at female patients with perturbed thyroid function. Sixty-seven long standing (over 6 months) overt hyperthyroid women had significantly lower bone mineral content as expressed by the Z score measured by quantitative ultrasonography (−0.86+/−0.69 ...

We present the case of a 40 year old man presenting at first consultation an ‘idiopathic’ fast-onset and severe polyuro-polydipsic syndrome (diuresis of 10 l/24 hours, with urine osmolality of less than 50 mOsm/kg and urine gravity lower than 1001). Clinical examination showed pallor and decreased pilosity at an asthenic patient with limited lesions of vitiligo and loss of libido. Water deprivation test showed the persistence of excretion of highly diluted amounts of...

The secretion of adipocytokines is influenced by fat mass, but also by various situations related to acute stress (food deprivation, or critical state related to inflamatory or infectious syndromes). Adipocytokinic secretory profile could be therefore used for the diagnosis of the type of critical state, as well for the evolution and survival prognosis of patients. The modifications of adipocytokinic markers during the first hours after surgical intervention are insufficiently...

Hashimoto’s thyroiditis is an autoimmnune condition most common in females but can be also found in children with a prevalence of 1.2%. When is associated with hypothyroidism, the growth delay is an important, but late symptom. We present the case of a 12-year-old boy presenting with small height for age (123 cm, <−3 S.D.), important weight gain and fatigue. He was the only child from parents of average height and had normal weight at birth (3300 ...

Introduction: Velocardiofacial syndrome (VCFS) also known as DiGeorge or chonotruncal anomaly face syndrome, is a rare genetic disease caused by a microdeletion in the long arm of chromosome 22, having a prevalence of approximately 1:7000 to 1:4000. VCFS has a wide spectrum of more than 200 physical manifestations including: cleft palate, heart and facial abnormalities, eye pathology, problems with feeding, including nasal regurgitation, middle-ear infections (otitis media), l...

We investigated calcium and bone metabolism in a group of 123 institutionalized volunteers between 60 and 98 years old, 73 females and 50 males. 25OH-D3 was measured by an indoor RIA technique. 1.25(OH)2D3 was measured by HPLC, serum calcium by photocolorimetry, bone alkaline phosphatase by immunoenzymatic technique, whereas serum PTH and urinary deoxypyridinoline (DPD) were measured by IRMA. Almost all volunteers (92.6%) had low 25OH-D3</...

In order to investigate the relationship between Graves’ disease, its associated ophthalmopathy and smoking, we followed retrospectively a group of 270 patients with Graves’ disease (233 females and 37 males). Smoking incidence within this group was compared to that found in a control, thyroid disease-free group of 120 patients. The incidence of smokers was significantly higher in the group with Graves’ disease (145 out of 270, 54%) when compared to the control ...

Gravitational stress influences bone mass. Adipose tissue represents a supplementary source of estrogens at postmenopausal women, via aromatization of androgens. We evaluated the importance of weight and fat tissue on bone mass at premenopausal or postmenopausal women in a cross-sectional study upon a group of 138 women between 25 and 77 ys old and with a BMI between 17.1 and 44.3 kg/m2. Fifty six women were menstruating, 15 were perimenopausal and 68 were po...

Topical application of corticosteroids is frequently used in the therapy of various dermatological diseases due to their antiinflammatory and immunsuppressive effects. Systemic pharmacological levels of glucocorticoids lead, on the other hand, to Cushing syndrome, i.e. significant modifications of intermediary metabolism, body composition, bone mass, haematolymphopoietic system and, last but not least, to skin modifications: purple striae, petechiae, infections. We describe a ...